Isotonitazene- synthetic opioid more potent than fentanyl

  1. Public Alert - N-Desethyl Isotonitazene

Xylazine - large animal tranquilizer mixed with fentanyl to prolong fentanyl action, no reversal agent, severe necrotic skin ulcerations

  1. 11-8-2022 FDA announcement
  2. FDA letter to stakeholders
  3. White House Action Plan